Feasibility and safety profile of high-dose oxaliplatin-based PIPAC (120mg/m2) in the treatment of advanced peritoneal metastatic disease: MINOS real-life multicenter study

High-dose PIPAC-Ox is feasible and safe. Local and histological response are well identified. However abdominal pain remains a main concern and continuous IV protocols should be considered routinely.

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Publication Details

Journal
European Journal of Surgical Oncology
Published
2026-03-05
DOI
https://doi.org/10.1016/j.ejso.2026.111731
Primary Topic
Intraperitoneal and Appendiceal Malignancies
Type
article
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article

Feasibility and safety profile of high-dose oxaliplatin-based PIPAC (120mg/m2) in the treatment of advanced peritoneal metastatic disease: MINOS real-life multicenter study

Guillaume De Meeus, V. Kepenekian, M Pocard, Olivier Glehen et al.
European Journal of Surgical Oncology
Intraperitoneal and Appendiceal Malignancies
article

Feasibility and safety profile of high-dose oxaliplatin-based PIPAC (120mg/m2) in the treatment of advanced peritoneal metastatic disease: MINOS real-life multicenter study

Guillaume De Meeus, V. Kepenekian, M Pocard, Olivier Glehen, Olivia Sgarbura, Francois Quenet, Abdelkader Taibi, Diego A. Zambrano, Amaniel Kefleyesus, Alexandru Lintis, Clarisse Eveno
article en

Abstract

High-dose PIPAC-Ox is feasible and safe. Local and histological response are well identified. However abdominal pain remains a main concern and continuous IV protocols should be considered routinely.

European Journal of Surgical OncologyVol. 52(5)
Inserm (FR), Centre Hospitalier Universitaire Vaudois (CH), Centre Hospitalier Universitaire de Lille (FR), Universidad Espíritu Santo (EC), Sorbonne Université (FR), Hôpital Lyon Sud (FR), Centre Hospitalier Universitaire de Limoges (FR), Pitié-Salpêtrière Hospital (FR), Institut de Recherche en Cancérologie de Montpellier (FR), Comisión Honoraria de Lucha contra el cáncer (UY), University of Lausanne (CH)
Openalex Percentile: Top 34%
Intraperitoneal and Appendiceal Malignancies
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