Colonic biopsy-associated microbial signatures are predictive of response to anti-TNFα biological therapy in Crohn’s disease
Taken together, this study demonstrates that the colonic mucosal microbiome prior to anti-TNFα treatment can distinguish responders from non-responders in CD, supporting its potential as a predictive biomarker.
Authors
- Ishtu Hageman (ORCID: https://orcid.org/0000-0002-3180-156X)
- V Joustra (ORCID: https://orcid.org/0000-0003-4157-7220)
- Mark Davids (ORCID: https://orcid.org/0000-0003-3081-9124)
- Konstantina Zafeiropoulou (ORCID: https://orcid.org/0000-0001-5061-4658)
- Theodorus B. M. Hakvoort (ORCID: https://orcid.org/0000-0002-5185-9611)
- Tianqi Mu
- Konstantinos Chronas
- R.M.J.G.J. van den Wijngaard
- Andrew Y. F. Li Yim
- W De Jonge
- P Koelink
- J Satsangi
- Geert R. D’Haens
Institutions
- University Hospital Bonn (DE)
- Nuffield Orthopaedic Centre (GB)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fcimb.2026.1741002
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Crohn's and Colitis Organisation