Membrane-targeted schiff base derivatives overcome MRSA resistance through phosphatidylglycerol binding and ROS-mediated killing
Compound <b>C12</b> represents a promising anti-MRSA lead compound. It combines potent antibacterial activity with a unique multi-mechanistic action targeting the cell membrane, a favorable biosafety profile, and a low resistance risk. These merits warrant further in-depth investigation and development.
Authors
- L T Hu
- Yaguang Liu
- Binbin Liu
- Zheng Qu
Institutions
- Qinhuangdao Second Hospital (CN)
Publication Details
- Journal
- Frontiers in Chemistry
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fchem.2026.1753350
- Primary Topic
- Synthesis and Characterization of Heterocyclic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00