Evaluation of Diabetes Mellitus, Hyperlipidemia, and Thyroid Disease Comorbidities in Palmoplantar Pustulosis

Background: Palmoplantar pustulosis (PPP) is a chronic, inflammatory pustular skin disease of unknown etiology. Genetic predisposition, smoking, focal infections, stress, and autoimmune diseases are implicated in its etiology. In this study, the presence of thyroid disease, diabetes mellitus (DM), and dyslipidemia in PPP was investigated based on comorbidities in psoriasis. Methods: The records of 51 patients who were diagnosed with PPP both clinically and histopathologically and presented to the dermatology clinic were examined retrospectively. In these patients, fasting blood sugar, HbA1C, serum lipids (cholesterol, triglyceride, low-density lipoprotein (LDL), high-density lipoprotein (HDL)), thyroid-stimulating hormone (TSH), free thyroxine (ft4), free triiodothyronine (ft3), antithyroglobulin (antiTG), antithyroid peroxidase antibody (antiTPO) were recorded, and the presence of DM, dyslipidemia, and thyroid disease was investigated. Compared with the control group. Results: The average age of the patients was 47.9 (Å}12.1) years and the average disease duration was 5 (3-12) years. In the patients, hypertriglyceridemia was found in 29.4%, hypercholesterolemia in 45.1%, high LDL in 44%, low HDL in 14%, thyroid disease in 11.76%, and DM in 21.5%. When these values were compared with the control group, triglyceride values were significantly higher in the patients compared to the controls (P < .001). Conclusions: Based on the data of this study, as in psoriasis, it could be suggested that there is a possibility of DM, dyslipidemia, and thyroid disease comorbidity with PPP. Cite this article as: Akbaş A, Kılın. F, Şener S, Hayran Y. Evaluation of diabetes mellitus, hyperlipidemia, and thyroid disease comorbidities in palmoplantar pustulosis. Eurasian J Med. 2026, 58(2), 1026, doi:10.5152/eurasianjmed.2026.251026.