ATR Blockade Potentiates the Effects of Genotoxic Agents In Vitro and Promotes Antitumor Immunity in a Mouse Model of Non-Small Cell Lung Cancer
These results demonstrate that ATR blockade concurrently enhances the efficacy of genotoxic agents and immune checkpoint inhibitors, thus paving the way for combination therapies in NSCLC.
Authors
- Christina Anna Papanikolaou
- Elisavet Deligianni
- Panagiotis Malamos (ORCID: https://orcid.org/0000-0002-5771-5352)
- Vassilis L. Souliotis (ORCID: https://orcid.org/0000-0002-2945-1329)
- Dimitra Mavroeidi
- Panagiota Stamou
- Konstantinos N. Syrigos
Institutions
- National and Kapodistrian University of Athens (GR)
- National Hellenic Research Foundation (GR)
- Sotiria General Hospital (GR)
Publication Details
- Journal
- Cancers
- Published
- 2026-03-03
- DOI
- https://doi.org/10.3390/cancers18050820
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AstraZeneca
- Εθνικό 'Ίδρυμα Ερευνών
- Hellenic Society of Medical Oncology