Retrorsine impairs liver regeneration by inducing progenitor cell-senescence <i>via</i> ROS after partial hepatectomy
When hepatocyte proliferation was completely suppressed by RTS, HPCs contributed minimally to liver regeneration owing to cellular senescence, resulting in regeneration failure.
Authors
- Jiangbo Ren (ORCID: https://orcid.org/0000-0002-9924-7032)
- Lei Li (ORCID: https://orcid.org/0000-0001-8723-3461)
- Hao Wang (ORCID: https://orcid.org/0000-0001-6881-9977)
- Xinyu Zhao (ORCID: https://orcid.org/0000-0002-5128-4424)
- Yan Cui (ORCID: https://orcid.org/0000-0002-5940-2886)
- Miaoran Yang
- Shan Shan
- Y He
- Lin Liu
- Ping Wang
- Jidong Jia
Institutions
- Capital Medical University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Beijing Friendship Hospital (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1080/07853890.2026.2635821
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Capital Medical University
- Peking University
- Beijing Nova Program