Low-dose chemotherapy remodels hepatic immune landscape and potentiates anti-tumor response to immune checkpoint blockade in cholangiocarcinoma
This study highlights that LDGC remodels the immunosuppressive microenvironment and potentiates anti-PD-L1 therapy, providing a rational regimen for ICC.
Authors
- Shi Mengchen
- Chenghao Zhao (ORCID: https://orcid.org/0009-0002-8794-1163)
- Shuqun Cheng
- Linsen Ye (ORCID: https://orcid.org/0000-0001-9632-1949)
- Wenjuan Li
- Siqi Li (ORCID: https://orcid.org/0000-0002-6166-8421)
- Chuan Wang (ORCID: https://orcid.org/0000-0002-9463-2644)
- Kun Li
- Liu Wei
- Wang Xiangyang
- Haoyuan Yu
- Hua Li
- Shuhong Yi
- Jiang Peng
- Lin Yuxi
- Lou Zhenbang
- Yongwei Hu
- Cao Yingjiao
- Liang Zhixing
Institutions
- Sun Yat-sen University (CN)
- Second Military Medical University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Guangzhou First People's Hospital (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Sun Yat-sen University Cancer Center (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Hepatology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1097/hep.0000000000001735
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00