Patients with symmetric Parkinson’s disease do poorly with subthalamic stimulation
This study provides class IIb evidence of worse ADL outcome of STN-DBS in patients with symmetric compared with asymmetric PD. Clinicians should counsel patients with symmetric PD on their elevated risk of ADL non-response when discussing STN-DBS as a treatment option.
Authors
- Stefanie T. Jost (ORCID: https://orcid.org/0000-0003-0477-2289)
- Philipp Alexander Loehrer (ORCID: https://orcid.org/0000-0002-5279-2156)
- A. Fasano
- Roberta Biundo (ORCID: https://orcid.org/0000-0001-5846-755X)
- Jonas Krauss
- Christopher Nimsky (ORCID: https://orcid.org/0000-0002-8216-9410)
- Julian Evans
- Lars Timmermann
- Per Borghammer
- J. N. Petry-Schmelzer
- Monty Silverdale
- Gereon Rudolf Fink
- Haidar S. Dafsari
- Jan F Krause
- Agni Maria Konitsioti
- David J Pedrosa
- Keyoumars Ashkan
- K Ray Chaudhuri
- Camilla Atwani
- Pablo Martinez-Martin
- The German Parkinson Society Non-Motor Symptoms Study Group
- Veerle Visser-Vandewalle
- Angelo Antonini
Institutions
- University of Padua (IT)
- Philipps University of Marburg (DE)
- University of Cologne (DE)
- University of Toronto (CA)
- Aarhus University (DK)
- Universitätsklinikum Gießen und Marburg (DE)
- Toronto Western Hospital (CA)
- University Hospital Bonn (DE)
- Manchester Academic Health Science Centre (GB)
- Salford Royal NHS Foundation Trust (GB)
- Dubai Hospital (AE)
- Aarhus University Hospital (DK)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- King's College Hospital NHS Foundation Trust (GB)
- UK Dementia Research Institute (GB)
- Krembil Foundation (CA)
- University Hospital Cologne (DE)
- Krembil Research Institute
Publication Details
- Journal
- Journal of Neurology Neurosurgery & Psychiatry
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1136/jnnp-2025-336382
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00