Effects of GPR110 expression on neurobehavioral outcomes in mice
Together, these findings demonstrate that GPR110 regulates anxiety-related and cognitive behaviors in adult mice and modulates synaptic and signaling pathways that support neuronal structure and communication. The GPR110-dependent mechanism as a new target for neurobehavioral modulation may provide a strategy to mitigate anxiety- and cognition-related pathophysiologic behavioral conditions.
Authors
- Mariam Melkumyan (ORCID: https://orcid.org/0000-0002-8957-7361)
- Hee‐Yong Kim
- Bill X. Huang
- Joel Toro
Institutions
- National Institute on Alcohol Abuse and Alcoholism (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fnins.2026.1774433
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health