Perivascular Spaces Are Associated With CSF Aβ in Cerebral Amyloid Angiopathy But Not in Deep Perforator Arteriopathy
Our findings strengthen the pathophysiological link between CSO PVS and Aβ pathology in CAA but not in DPA. These results extend previous histopathologic and neuroimaging work and underscore the need to interpret CSO PVS in the context of underlying CSVD subtype.
Authors
- Malte Pfister
- Cornelia Garz
- Hendrik Mattern (ORCID: https://orcid.org/0000-0001-5740-4522)
- Marc Dörner (ORCID: https://orcid.org/0000-0003-3229-1677)
- Sebastian Johannes Müller
- Katja Neumann
- Philipp Arndt
- Jose M Bernal
- Valentina Perosa
- Patrick Müller
- Sven G. Meuth
- Stefanie Schreiber
Institutions
- Helmholtz Association of German Research Centres (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University of Zurich (CH)
- German Center for Neurodegenerative Diseases (DE)
- Massachusetts General Hospital (US)
- University Hospital of Zurich (CH)
- German Center for Lung Research (DE)
- Heinrich Heine University Düsseldorf (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
- University of Edinburgh (GB)
Publication Details
- Journal
- Stroke
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1161/strokeaha.125.053794
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00