Case Report: Allogeneic hematopoietic stem cell transplantation in a patient with triple-allele expression at both HLA-B and HLA-C loci
This case highlights an extremely rare immunogenetic configuration in which triple-allele expression at two HLA class I loci directly influenced donor selection for allo-HSCT. Comprehensive interpretation of HLA typing results, including family analysis and protein-level expression, is essential when such atypical findings are encountered.
Authors
- Saki Takahashi (ORCID: https://orcid.org/0000-0001-5413-5507)
- Hidenori Tanaka (ORCID: https://orcid.org/0000-0001-6169-290X)
- Yusuke Kino
- Mami Samori (ORCID: https://orcid.org/0000-0003-3462-9205)
- Kyoko Yoshihara (ORCID: https://orcid.org/0009-0001-9578-4850)
- Yoshiyuki Fujita
- Fuyuki Yamagata
- Satoshi Yoshihara
- Daisuke Takahashi
Institutions
- Japanese Red Cross Society, Japan (JP)
- Tula Foundation (CA)
- Cellular Therapeutics (United Kingdom) (GB)
- Hyogo University (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fimmu.2026.1785227
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00