Risk of neurodevelopmental disorders associated with paternal use of valproate during spermatogenesis
In this large Nordic study, paternal valproate use during spermatogenesis was not associated with increased risk of NDDs in offspring, suggesting current regulatory restrictions may warrant re-evaluation.
Authors
- Julie Werenberg Dreier (ORCID: https://orcid.org/0000-0002-9339-4170)
- Jannicke Igland (ORCID: https://orcid.org/0000-0002-2289-0978)
- Torbjörn Tomson
- Neda Razaz
- Jonas K. Söderling (ORCID: https://orcid.org/0000-0001-9006-2835)
- Marte-Helene Bjørk
- J Christensen
Institutions
- Karolinska University Hospital (SE)
- Western Norway University of Applied Sciences (NO)
- Aarhus University (DK)
- Haukeland University Hospital (NO)
- Aarhus University Hospital (DK)
- Karolinska Institutet (SE)
- University of Bergen (NO)
Publication Details
- Journal
- Journal of Neurology Neurosurgery & Psychiatry
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1136/jnnp-2025-337441
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eisai
- Novo Nordisk
- Novo Nordisk Fonden
- Region Midtjylland