Development of coronary artery disease in patients with initially normal coronary arteries in the SCOT-HEART trial
Question In patients with normal coronary arteries on coronary computed tomography angiography (CCTA), the risk of developing CAD in the future is uncertain. Findings Among 524 patients with normal coronaries, CAD was identified on 48% of CCTA and 25% of chest CT during 10 years of follow-up. Clinical relevance A substantial proportion of patients with initially normal coronary arteries on CCTA later develop CAD, highlighting the need for clinicians to be alert for the development of new CAD in patients with initially normal coronary arteries.
Authors
- Phyo Khaing (ORCID: https://orcid.org/0000-0001-8489-0837)
- Krystalina Y T Sim
- Alan Ranieri Guimaraes
- Giles Roditi
- Jenny Ramsay
- Lia Avigdor
- Michelle C. Williams
- Kayleigh Wood
- Marc R. Dweck
- Nicholas L. Mills
- Steven E. Williams
- David E. Newby
Institutions
- British Heart Foundation (GB)
- University of Glasgow (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- European Radiology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1007/s00330-026-12353-6
- Citations
- 1
- Primary Topic
- Cardiac Imaging and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 31.92
Funders
- Israel Cancer Research Fund
- Scottish Government
- British Heart Foundation
- Chief Scientist Office, Scottish Government Health and Social Care Directorate