Alkaline Phosphatase Supplementation During Hypothermic and Normothermic Machine Perfusion Improves Metabolic Dysfunction in a Porcine Model of Donor Kidney Preservation
ALP supplementation during HMP was associated with lower urine production and energetic stress, with a shift toward less metabolic dysfunction and graft injury by the end of NMP. Our findings suggest an improvement in the early metabolic incompetency that characterizes delayed graft function in humans. Further research should elucidate whether these findings result in enhancement of graft functionality after transplantation.
Authors
- Thei Steenvoorden (ORCID: https://orcid.org/0000-0001-6953-3647)
- Alessandra Tammaro (ORCID: https://orcid.org/0000-0003-3128-5259)
- Bemelman Fj
- J. Garcia (ORCID: https://orcid.org/0009-0004-6771-1664)
- Sandrine Florquin
- Liffert Vogt
- Janneke A. J. Rood
- Joost W. van der Heijden
- Henri Leuvenink
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Amsterdam UMC Location University of Amsterdam (NL)
- Spaarne Ziekenhuis (NL)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- Spaarne Gasthuis (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Transplantation Direct
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1097/txd.0000000000001929
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00