Co-infection of Cystoisospora suis with enterotoxigenic Escherichia coli synergistically increases pathogenicity in weaned piglets

Co-infection with C. suis and ETEC exerts a synergistic pathogenic effect in weaned piglets. The mechanism involves a vicious cycle of intestinal barrier disruption, microbiota dysbiosis, and amplified inflammatory responses. These findings provide a novel theoretical basis for the clinical prevention and control of complex intestinal co-infections.