Unraveling the Complexities of Small Intestinal Bacterial Overgrowth

This narrative review explores the intricate dynamics of Small Intestinal Bacterial Overgrowth (SIBO), a condition marked by an excessive growth of bacteria in the small intestine. We delve into the multifaceted etiology of SIBO, including its associations with gastrointestinal disorders, motility issues, and alterations in gut architecture. The review examines current diagnostic methodologies, emphasizing the distinctions between breath testing and direct aspiration techniques. Furthermore, we assess the various treatment approaches, ranging from antibiotics and dietary modifications to emerging therapeutic options. By synthesizing the latest research findings, we aim to enhance understanding of SIBO's implications for gut health and provide insights into effective management strategies.

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Publication Details

Journal
Medicina
Published
2026-03-04
DOI
https://doi.org/10.3390/medicina62030485
Primary Topic
Gastrointestinal motility and disorders
Type
article
Field-Weighted Citation Impact
0.00
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Unraveling the Complexities of Small Intestinal Bacterial Overgrowth

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Gastrointestinal motility and disorders
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Unraveling the Complexities of Small Intestinal Bacterial Overgrowth

Sara Sofia De Lucia, Veronica Ojetti, Carmine Petruzziello, Angelo Del Gaudio, Enrico Capuano, Giuseppe Cuccia, Antonio Pellegrino, Enrico Celestino Nista, Angela Saviano
article en

Abstract

This narrative review explores the intricate dynamics of Small Intestinal Bacterial Overgrowth (SIBO), a condition marked by an excessive growth of bacteria in the small intestine. We delve into the multifaceted etiology of SIBO, including its associations with gastrointestinal disorders, motility issues, and alterations in gut architecture. The review examines current diagnostic methodologies, emphasizing the distinctions between breath testing and direct aspiration techniques. Furthermore, we assess the various treatment approaches, ranging from antibiotics and dietary modifications to emerging therapeutic options. By synthesizing the latest research findings, we aim to enhance understanding of SIBO's implications for gut health and provide insights into effective management strategies.

MedicinaVol. 62(3)
Università Cattolica del Sacro Cuore (IT), Agostino Gemelli University Polyclinic (IT), Saint Camillus International University of Health and Medical Sciences (IT), Ospedale San Carlo (IT), Ospedale Veris Delli Ponti Scorrano (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Openalex Percentile: Top 34%
Gastrointestinal motility and disorders
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