The potential of allogeneic demineralized dentin matrix in clinical oral surgery: a narrative review

Background: The development of alternatives to autologous bone grafts remains crucial in oral surgery to overcome donor site morbidity and limited availability. Autogenous demineralized dentin matrix (Auto-DDM) has been clinically utilized in various forms, yet its dependence on extractable teeth, lack of standardized processing, and patient preference limit its use. Findings: Preclinical studies demonstrate that allogeneic demineralized dentin matrix (Allo-DDM) exhibits strong osteogenic potential and minimal antigenicity, even in extraosseous applications. Recent evidence extends its efficacy to clinical applications, confirming biocompatibility and bone-forming capacity comparable to Auto-DDM, without the limitations of donor tooth availability. Conclusions: Allo-DDM emerges as a promising bone substitute, supported by robust preclinical data. This review highlights its potential for clinical translation, advocating for further research to standardize processing and validate its safety and effectiveness in human applications.