Preventing Hand-Foot Syndrome in Patients With Cancer
In this systematic review and network meta-analysis, diclofenac and silymarin were the most effective preventive strategies for HFS, with silymarin requiring confirmation in a larger randomized trial. Diclofenac emerged as the agent with the best overall supporting evidence, informed by both effect estimates and study quality.
Authors
- Neha Pathak (ORCID: https://orcid.org/0000-0003-1839-8558)
- Mohit Kumar Divakar (ORCID: https://orcid.org/0000-0002-6731-9249)
- Chitrakshi Nagpal (ORCID: https://orcid.org/0000-0002-7352-2446)
- Payal Vasudeva
- Hemavathi Baskarane (ORCID: https://orcid.org/0000-0003-0946-8518)
- Shubham Sahni
- R. P. Agarwal (ORCID: https://orcid.org/0000-0002-1804-7873)
- Vishakha Hooda
- Atul Batra
- Sameer Bakhshi
- Pranav Pratap Singh
- Hari Krishna Raju Sagiraju
- Sudhir Kumar
Institutions
- All India Institute of Medical Sciences (IN)
Publication Details
- Journal
- JAMA Dermatology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1001/jamadermatol.2026.0042
- Primary Topic
- Chemotherapy-related skin toxicity
- Type
- article
- Field-Weighted Citation Impact
- 0.00