Sentinel lymph node biopsy versus lymphadenectomy in early-stage cervical cancer: a meta-analysis of oncologic outcomes and surgical morbidity

This study suggests that SLNB provides oncologic outcomes comparable to LND while reducing surgical morbidity in early-stage cervical cancer. The inclusion of CSS as a validated endpoint reinforces the cancer-specific safety of SLNB, with no significant compromise observed in either OS or PFS. While current evidence is promising, further large-scale prospective trials are needed to refine indications and standardize implementation of SLNB in routine clinical practice.

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Publication Details

Journal
Frontiers in Oncology
Published
2026-03-04
DOI
https://doi.org/10.3389/fonc.2026.1765529
Primary Topic
Endometrial and Cervical Cancer Treatments
Type
article
Field-Weighted Citation Impact
0.00

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article

Sentinel lymph node biopsy versus lymphadenectomy in early-stage cervical cancer: a meta-analysis of oncologic outcomes and surgical morbidity

Siyuan Zeng, Ruiqi Wang, Chao Xiao, Xue Xiao et al.
Frontiers in Oncology
Endometrial and Cervical Cancer Treatments
article

Sentinel lymph node biopsy versus lymphadenectomy in early-stage cervical cancer: a meta-analysis of oncologic outcomes and surgical morbidity

Siyuan Zeng, Ruiqi Wang, Chao Xiao, Xue Xiao, Luying Li
article en

Abstract

This study suggests that SLNB provides oncologic outcomes comparable to LND while reducing surgical morbidity in early-stage cervical cancer. The inclusion of CSS as a validated endpoint reinforces the cancer-specific safety of SLNB, with no significant compromise observed in either OS or PFS. While current evidence is promising, further large-scale prospective trials are needed to refine indications and standardize implementation of SLNB in routine clinical practice.

Frontiers in OncologyVol. 16
Sichuan University (CN), West China Second University Hospital of Sichuan University (CN), Zigong First People's Hospital (CN)
National Key Research and Development Program of China
Openalex Percentile: Top 32%
Endometrial and Cervical Cancer Treatments
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Sentinel lymph node biopsy versus lymphadenectomy in early-stage cervical cancer: a meta-analysis of oncologic outcomes and surgical morbidity — Siyuan Zeng, Ruiqi Wang, et al. · Frontiers in Oncology (2026) | TGRS Research Map | TGRS