Effect of Recombinant Tissue-Type Plasminogen Activator on Peripheral Blood Mononuclear Cells of Patients With Alteplase-Associated Angioedema
These preliminary data suggest that R-tPA-related angioedema may result from abnormal immune cell activation, leading to increased release of vasoactive mediators. This immune dysregulation may contribute to the pathophysiology of angioedema in susceptible IS patients treated with R-tPA.
Authors
- S Loffredo
- F Palestra
- S Miniello
- R Gualtierotti
- R Ciardi
- C Suffritti
- G Varricchi
- M Tarsitano
- V. Andreone
- M Bova
- G Servillo
- R Cavallaro
- M Chetta
- A Ferrara
- P Candelaresi
Institutions
- University of Milan (IT)
- Hereditary Disease Foundation (US)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Ospedale Antonio Cardarelli (IT)
- Ospedale Sant'Anna (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Journal of Investigational Allergology and Clinical Immunology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.18176/jiaci.1146
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00