Suppressed gonadotropins as a warning sign of anextragonadal tumor in an adolescent with Klinefeltersyndrome

Patients with Klinefelter syndrome have an increased risk of certain neoplasms, particularly germ cell tumors, especially those located outside the gonads. We report a case of a mediastinal germ cell tumor in an adolescent patient. The diagnosis was reached based on unusual gonadotropin values.

Publication Details

Journal
Archivos Argentinos de Pediatria
Published
2026-03-04
DOI
https://doi.org/10.5546/aap.2025-10916.eng
Primary Topic
Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Type
article
Field-Weighted Citation Impact
0.00
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article

Suppressed gonadotropins as a warning sign of anextragonadal tumor in an adolescent with Klinefeltersyndrome

Archivos Argentinos de Pediatria
Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
article

Suppressed gonadotropins as a warning sign of anextragonadal tumor in an adolescent with Klinefeltersyndrome

article en

Abstract

Patients with Klinefelter syndrome have an increased risk of certain neoplasms, particularly germ cell tumors, especially those located outside the gonads. We report a case of a mediastinal germ cell tumor in an adolescent patient. The diagnosis was reached based on unusual gonadotropin values.

Archivos Argentinos de PediatriaVol. 124(5)
Good health and well-being
Openalex Percentile: Top 35%
Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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