Carbohydrate fatty acid monosulphate ester adjuvant enhances the immunogenicity of influenza antigens via TLR4/2-dependent mechanisms
CMS enhances influenza antigen immunogenicity by promoting TLR4/2-dependent DC activation, inflammatory signaling, and improved antigen presentation. These findings define the mechanistic basis of CMS adjuvanticity and support its development as a promising adjuvant platform for next-generation influenza vaccines targeting emerging pandemic strains.
Authors
- Mano Joseph Mathew (ORCID: https://orcid.org/0000-0002-4930-6903)
- Suraj Singh (ORCID: https://orcid.org/0000-0003-2895-4079)
- Max M Søgaard
- Ida Busch Nielsen
- Camille Chauvin
- Luuk Hilgers
- Srinivasa Reddy Bonam (ORCID: https://orcid.org/0000-0002-2888-2418)
- Sruthi Vijaya Retnakumar
- Christine Boyle
- Peter Paul Platenburg
Institutions
- Université Paris-Panthéon-Assas (FR)
- Conservatoire National des Arts et Métiers (FR)
- Indian Institute of Chemical Biology (IN)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- ExpreS2ion Biotechnologies (Denmark) (DK)
- Sorbonne Paris Cité (FR)
- Centre de Recherche des Cordeliers (FR)
- Indian Institute of Technology Palakkad (IN)
- Génomique Bioinformatique et Applications (FR)
- EpiVax (United States) (US)
- Vitenparken (NO)
- Indian Institute of Chemical Technology (IN)
- Limerick Institute of Technology (IE)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fimmu.2026.1787181
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Indian Institute of Technology Palakkad
- European Commission
- Horizon 2020 Framework Programme