Metastatic iris lesion from non-small cell lung cancer primary

Fig. 1 Metastatic iris lesion from non-small cell lung cancer primary.Anterior segment photograph of a large actively shedding exophytic right iris lesion with cystic components filling most of the anterior chamber with peripheral corneal touch (A, B) in a 51-year-old female presenting with a one-month history of progressive right vision loss (BCVA HM) and intermittent brow ache (IOP 14 mmHg).B-scan revealed a hypoechoic iris mass (C, arrow) with no ciliary body extension or posterior segment involvement (C).The diagnosis of unilateral iris metastasis from a known, already metastatic, non-small cell lung cancer (EGFR wild type) primary (D) was made.This is a rare manifestation [1, 2], especially in NSCLC.In addition to the radiation and chemotherapy already prescribed, the patient proceeded to receive external beam radiation therapy delivering 20 Gy in 5 fractions to the right eye which provided minimal subjective improvement in vision and symptoms.