Epidemiological relevant effect biomarkers for thyroid hormone system related adverse outcome pathways: a literature review
This review operationalizes the AOP framework to support the use of mechanistically anchored effect biomarkers in human studies on THSD. By aligning key biological events with measurable endpoints, human matrices, and feasibility considerations, it provides a scientifically grounded path from mechanistic understanding to population research application. This enables more targeted biomonitoring, strengthens interpretation of epidemiological findings, and informs research and regulatory priorities for future validation efforts.
Authors
- Maria Wielsøe (ORCID: https://orcid.org/0000-0003-1227-2065)
- Antonios Stratidakis (ORCID: https://orcid.org/0000-0002-9919-2158)
- Eva Cecilie Bonefeld‐Jørgensen (ORCID: https://orcid.org/0000-0001-5043-5553)
- E. Renieri
- Manhai Long
- Dimosthenis A. Sarigiannis
Institutions
- Ilisimatusarfik (GL)
- Aarhus University (DK)
- Aristotle University of Thessaloniki (GR)
- National Hellenic Research Foundation (GR)
- Institute for Advanced Study (DE)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fphar.2026.1760820
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- HORIZON EUROPE Framework Programme