Ascorbic acid enhances in vitro primordial germ cell-like cell differentiation from mouse ESCs
Building upon this finding, we established a highly efficient and reproducible protocol for in vitro PGCLC differentiation from mouse embryonic stem cells (mESCs) by modulating epigenetic regulation through AA. This system provides a valuable platform for dissecting the molecular mechanism and epigenetic reprograming during early germ cell development and potential therapeutic applications.
Authors
- Nithyapriya Kumar
- Umesh Kumar (ORCID: https://orcid.org/0000-0002-6226-0305)
- P. Chandra Shekar
- Kumarasamy Thangaraj
Institutions
- Centre for Cellular and Molecular Biology (IN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fcell.2026.1755998
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Council of Scientific and Industrial Research, India