DNA2 acts as a brake on β cell insulin hypersecretion and diet-induced metabolic dysfunction
Our findings identify DNA2 as a negative regulator of mitochondrial bioenergetics and insulin secretion in β cells. By limiting mitochondrial activity, DNA2 serves as a rheostat that prevents β cell overactivation during metabolic stress, thereby preserving systemic glucose homeostasis.
Authors
- Xianghui Fu (ORCID: https://orcid.org/0000-0002-7748-3907)
- Dongmei Tang
- Meilin Ma (ORCID: https://orcid.org/0000-0002-7212-5385)
- Haixia Xu
- Na Yang
- Yan Tian
Institutions
- Sichuan University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fcell.2026.1733190
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Northeast Forestry University
- Zhejiang University
- Sichuan University
- West China Hospital, Sichuan University