Astragalus small molecules protect BMSCs from radiation-induced bystander effect and enhance lung cancer radiosensitivity via the primary cilium/TGF-βR1/Smad3 pathway
Primary cilia play a key role in the repair of radiation-induced DNA damage in adjacent BMSCs and in enhancing the radiosensitivity of lung cancer. Vanillic acid and rosewood in <i>A. membranaceus</i> small molecules can regulate DNA damage in BMSCs through the TGF-βR1/primary cilia.
Authors
- Zhiming Miao (ORCID: https://orcid.org/0000-0001-7521-4925)
- Y.-L. Liu
- Sichao Dai
- Mengyuan Wu (ORCID: https://orcid.org/0000-0002-4213-7174)
- Liu Zhi-wei
- Liying Zhang
- Yang Yang Li
- Xin Wang
- Fuxian Liu
Institutions
- Gansu University of Traditional Chinese Medicine (CN)
- Jining Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fonc.2026.1732029
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Gansu University of Chinese Medicine