The role of OSM/OSMRβ axis in shaping the tumor microenvironment favoring MASLD-related HCC immune evasion
Our findings provide compelling evidence for an autocrine role of the OSM/OSMRβ axis in promoting CCL15 production by tumor cells, which, in turn, stimulates an immunosuppressive TIME in MASH-HCCs, suggesting OSM as a potential therapeutic target for HCC treatment.
Authors
- Stefania Cannito (ORCID: https://orcid.org/0000-0001-9883-6882)
- Jessica Nurcis
- Gian Paolo Caviglia (ORCID: https://orcid.org/0000-0002-0529-9481)
- Marta Anna Kowalik (ORCID: https://orcid.org/0000-0001-9868-5674)
- Emanuele Albano (ORCID: https://orcid.org/0000-0003-4738-7049)
- Patrizia CARUCCI
- Ignazia Tusa (ORCID: https://orcid.org/0000-0002-9198-2630)
- Cristina Vecchio
- F. Doto
- E. Novo
- Alessio Menconi (ORCID: https://orcid.org/0000-0001-8264-7462)
- Claudia Bocca
- Ugo Chianese (ORCID: https://orcid.org/0000-0003-2726-1895)
- Beatrice Foglia (ORCID: https://orcid.org/0000-0001-7973-9681)
- Maurizio Parola
- Andrea Caddeo (ORCID: https://orcid.org/0000-0002-4957-9493)
- Andr Perra
- Salvatore Sutti (ORCID: https://orcid.org/0000-0002-0192-8199)
- Elisabetta Rovida (ORCID: https://orcid.org/0000-0002-5949-3239)
- Marina Maggiora
- Rosaria Benedetti
- A. Provera
- Renato Romagnoli
- Lucia Altucci
- Francesca Bossi
- Chiara Rosso
- Elisabetta Bugianesi
- Silvia Gaia
- Alessandro Gambella
Institutions
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- University of Cagliari (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Fatebenefratelli Hospital (IT)
- Biogem (IT)
- Department of Medical Sciences (BY)
- University of Florence (IT)
- University of Turin (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Hepatology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1097/hep.0000000000001733
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00