Paeonol inhibits the development of oral squamous cell carcinoma through the PI3K/AKT signaling pathway
Pae suppressed OSCC cell proliferation and EMT and was associated with mitochondrial apoptosis and activation of autophagic flux, accompanied by reduced PI3K/AKT phosphorylation. Co-treatment with 3-methyladenine (3-MA) further decreased cell viability and enhanced apoptosis-associated changes, suggesting that pharmacological co-targeting of PI3K signaling and autophagy may potentiate Pae's antitumor activity. Further studies are warranted to delineate the relative contributions of apoptosis and autophagy to Pae-induced cytotoxicity in OSCC.
Authors
- Changyue Liu (ORCID: https://orcid.org/0000-0003-2865-5749)
- Han Jz
- Ruomei Li (ORCID: https://orcid.org/0000-0003-0213-3301)
- Yi Liu (ORCID: https://orcid.org/0000-0002-1058-0382)
- Xuelin Mou
- Jiaming Liu (ORCID: https://orcid.org/0000-0001-8444-9136)
- Yuehan Wu
- Yuxia Gao
Institutions
- North Sichuan Medical University (CN)
- Nanchang University (CN)
- Changsha Medical University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fcell.2026.1747424
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00