SCGB1A1 suppresses prostate cancer proliferation and metastasis by modulating the MAPK signaling pathway
Our findings identify SCGB1A1 as a previously underappreciated tumor-suppressive role in prostate cancer and reveal its role in modulating MAPK signaling and EMT. The depletion of SCGB1A1⁺ epithelial cells characterizes the malignant epithelial phenotype, suggesting its potential as a candidate diagnostic biomarker and therapeutic target that requires further clinical validation.
Authors
- Xudong Zhou (ORCID: https://orcid.org/0000-0002-8065-3030)
- Guisong Qi
- Wanli Zhao
- Yan Zhou (ORCID: https://orcid.org/0009-0007-2223-0113)
- Fan li
Institutions
- Cangzhou Central Hospital (CN)
Publication Details
- Journal
- International Urology and Nephrology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1007/s11255-026-05076-6
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00