Higher fibrinogen levels contributes to thrombosis in intracranial atherosclerosis-related large vessel occlusion strokes
ICAS-LVOS exhibits a unique profile distinct from AF-LVOS and sICAS. Fibrinogen appears to play a significant role in thrombogenesis and the occurrence of LVOS in ICAS, influencing thrombus characteristics and potentially modifying the efficacy of thrombolysis in specific patient subgroups.
Authors
- Hongyun Zhao (ORCID: https://orcid.org/0000-0002-1251-3888)
- Yimeng Liu (ORCID: https://orcid.org/0000-0002-6742-2908)
- Yifeng Ling
- An Yu
- Zigao Wang (ORCID: https://orcid.org/0000-0002-7109-0096)
- Fangzhe Chen (ORCID: https://orcid.org/0000-0002-7466-7401)
- Qiang Dong
Institutions
- Fudan University (CN)
- National Clinical Research (US)
- Huashan Hospital (CN)
- Institute of Neurobiology (BG)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fneur.2026.1753192
- Primary Topic
- Blood properties and coagulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Science and Technology Major Project