DNA Hypermethylation Suppresses Thyroid Peroxidase Expression and May Be a Promising Diagnostic Marker for Thyroid Cancer
DNA hypermethylation suppresses TPO transcription by recruiting MBD2 in thyroid cancer. Quantitative assessment of <i>TPO</i> methylation by pyrosequencing offers a promising molecular diagnostic approach to distinguish malignant cancer from BTN. Further studies are warranted to ascertain the clinical diagnostic utility of these findings.
Authors
- Jiayong Huang
- Yijia Chen (ORCID: https://orcid.org/0000-0002-9295-5028)
- Lefan Zhu
- Guanghui Hu (ORCID: https://orcid.org/0000-0002-5089-4052)
- BL Lin
- Rengyun Liu
- Pinning Feng
- Qi Zhang
- Ke Jiang
- Weiming Lv
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Thyroid
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1177/10507256261427034
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00