Pathogenic diversity of Klebsiella pneumoniae strains with different serotypes and sequence types from human liver abscess
Specific serotype-STs combination potentiates lethality under certain circumstances (e.g., K2-ST65), but its impact is complicated. Novel STs correlate with acute lethality (K1) or atypical tropism (K80 lung-specific virulence). These findings highlight strain-specific virulence mechanisms, which are critical for the risk stratification of <i>K. pneumoniae</i> infection.
Authors
- Zihui Yu (ORCID: https://orcid.org/0000-0002-3468-7782)
- Zheng Fan (ORCID: https://orcid.org/0000-0003-1934-2521)
- Yuehua Ke
- Junxia Feng (ORCID: https://orcid.org/0009-0006-1610-2476)
- X. Yan Liu
- Xue Ren
- Lei Huang (ORCID: https://orcid.org/0000-0003-3483-5340)
- Tongtong Fu
- Lin Gan (ORCID: https://orcid.org/0000-0001-5374-6277)
- Jinghua Cui
- Hanqing Zhao
- Yanling Feng
- Guanhua Xue
- Jing Yuan
- Yang Yang
- Chao Yan
- Bing Du
- An Su
- Yujie Chen
- Ziying Xu
- Tingting Zhang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Peking Union Medical College Hospital (CN)
- University Teaching Hospital (ZM)
- Chinese PLA General Hospital (CN)
- Center for Children (US)
- Capital Institute of Pediatrics (CN)
- Capital Health (US)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fmicb.2026.1730966
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China