Postnatal expression of the transcription factor Ebf2 in motivation, reward, and pain-related circuits of the mouse brain

The results demonstrate that Ebf2 expression persists beyond embryonic development and is selectively enriched in neural circuits associated with motivation, reward processing, and nociceptive modulation. The marked reduction of Ebf2-TGFP expressing neurons in null mutants provides evidence for a postnatal requirement of Ebf2 in neuronal maintenance, rather than solely in early differentiation. Collectively, these findings broaden the functional scope of Ebf2 to include postnatal circuit stabilization and support its sustained regulatory role in brain systems that govern affective and pain-related behaviors.

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Publication Details

Journal
Frontiers in Neuroanatomy
Published
2026-03-04
DOI
https://doi.org/10.3389/fnana.2026.1780361
Primary Topic
Genetics and Neurodevelopmental Disorders
Type
article
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article

Postnatal expression of the transcription factor Ebf2 in motivation, reward, and pain-related circuits of the mouse brain

Viviana Zomosa‐Signoret, Jesús Santana-Solano, Moisés Martínez-Estrada, Mara C. Obregón-Fuentes et al.
Frontiers in Neuroanatomy
Genetics and Neurodevelopmental Disorders
article

Postnatal expression of the transcription factor Ebf2 in motivation, reward, and pain-related circuits of the mouse brain

Viviana Zomosa‐Signoret, Jesús Santana-Solano, Moisés Martínez-Estrada, Mara C. Obregón-Fuentes, Moisés Santillán-Zerón, Melani A. Balderas-Díaz, A. Damaris Salinas-Villarreal, Román Vidaltamayo, Danna A. Real-Marín, M. Blanca D. Cepeda-Varela
article en

Abstract

The results demonstrate that Ebf2 expression persists beyond embryonic development and is selectively enriched in neural circuits associated with motivation, reward processing, and nociceptive modulation. The marked reduction of Ebf2-TGFP expressing neurons in null mutants provides evidence for a postnatal requirement of Ebf2 in neuronal maintenance, rather than solely in early differentiation. Collectively, these findings broaden the functional scope of Ebf2 to include postnatal circuit stabilization and support its sustained regulatory role in brain systems that govern affective and pain-related behaviors.

Frontiers in NeuroanatomyVol. 20
Instituto de Estudios Avanzados (VE), Universidad Autónoma de Chiapas (MX), Centro de Investigación en Materiales Avanzados (MX), Universidad Ateneo de Monterrey (MX), Instituto Politécnico Nacional (MX), University of Monterrey (MX)
Openalex Percentile: Top 35%
Genetics and Neurodevelopmental Disorders
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Postnatal expression of the transcription factor Ebf2 in motivation, reward, and pain-related circuits of the mouse brain — Viviana Zomosa‐Signoret, Jesús Santana-Solano, et al. · Frontiers in Neuroanatomy (2026) | TGRS Research Map | TGRS