Pharmacogenomics of response to interferon-beta and glatiramer acetate in Multiple Sclerosis: A multi-centric study
This study identified novel genetic variants for GA response, implicating genes in crucial pathways. For IFN-β, suggestive signals point to immune and interferon-related genes. These findings enhance our understanding of genetic influences on RRMS treatment response, while highlighting pharmacogenomic research challenges.
Authors
- Sandra D’Alfonso (ORCID: https://orcid.org/0000-0002-3983-9925)
- Kimmo Pääkkönen
- Melissa Sorosina (ORCID: https://orcid.org/0000-0003-4376-2550)
- Alen Zollo (ORCID: https://orcid.org/0009-0005-0908-7469)
- M. Filippi
- Alberto Priori (ORCID: https://orcid.org/0000-0002-1549-3851)
- Klementy Shchetynsky (ORCID: https://orcid.org/0000-0003-4578-5588)
- Saarela Janna
- Alessandra Mingione (ORCID: https://orcid.org/0000-0001-8008-0191)
- Pernilla Stridh
- Antonino Giordano (ORCID: https://orcid.org/0000-0003-3657-7584)
- Hanne Flinstad Harbo
- Fredrik Piehl
- Maria Assunta Rocca
- Andrea Corona
- An Goris
- Bénédicte Dubois
- Ingrid Kockum
- Tomas Olsson
- Finn Sellebjerg
- Helle Bach Søndergaard
- Filippo Martinelli Boneschi
- Elisabetta Mascia
- Ferdinando Clarelli
- Adil Harroud
- Bernhard Hemmer
- Federica Esposito
Institutions
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Oslo University Hospital (NO)
- Montreal Neurological Institute and Hospital (CA)
- Allen Institute for Brain Science (US)
- Karolinska University Hospital (SE)
- University of Helsinki (FI)
- Vita-Salute San Raffaele University (IT)
- University of Milan (IT)
- Copenhagen University Hospital (DK)
- TUM Klinikum (DE)
- Rigshospitalet (DK)
- Karolinska Institutet (SE)
- Ospedale San Paolo (IT)
- Institute for Molecular Medicine Finland (FI)
- Danish Multiple Sclerosis Center (DK)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- Technical University of Munich (DE)
Publication Details
- Journal
- Multiple Sclerosis Journal
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1177/13524585261417130
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00