MLPH/RAB3A accelerates the differentiation of pancreatic stem cells to islet β-cells to control blood glucose in diabetic rats

MLPH overexpression is favourable for the differentiation of PSCs to insulin β-cells. Transplantation of MLPH-overexpressing PSC-β cells restored the ability of T1D rats to manage a glycemic load by promoting RAB3A expression.

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Publication Details

Journal
Organogenesis
Published
2026-03-03
DOI
https://doi.org/10.1080/15476278.2026.2630542
Primary Topic
Pancreatic function and diabetes
Type
article
Field-Weighted Citation Impact
0.00
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article

MLPH/RAB3A accelerates the differentiation of pancreatic stem cells to islet β-cells to control blood glucose in diabetic rats

Junling Shan, Huifeng Wang, Guangyu Zhu
Organogenesis
Pancreatic function and diabetes
article

MLPH/RAB3A accelerates the differentiation of pancreatic stem cells to islet β-cells to control blood glucose in diabetic rats

Junling Shan, Huifeng Wang, Guangyu Zhu
article en

Abstract

MLPH overexpression is favourable for the differentiation of PSCs to insulin β-cells. Transplantation of MLPH-overexpressing PSC-β cells restored the ability of T1D rats to manage a glycemic load by promoting RAB3A expression.

OrganogenesisVol. 22(1)
Guangxi Medical University (CN)
Openalex Percentile: Top 34%
Pancreatic function and diabetes
DOIOpen Access PDFOpenAlex
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MLPH/RAB3A accelerates the differentiation of pancreatic stem cells to islet β-cells to control blood glucose in diabetic rats — Junling Shan, Huifeng Wang, et al. · Organogenesis (2026) | TGRS Research Map | TGRS