Morphological changes and lateralization of the thalamic nuclei in children with growth hormone deficiency
The observed leftward lateralization in the anterior thalamic nuclei, together with associations with serum IGF-1 and IGFBP-3 levels, suggests that thalamic lateralization reflects a neurodevelopmental adaptation to disrupted GH signaling. These findings suggest that GH/IGF activity shapes subcortical development in a dose-dependent manner and reveal structural adaptations in hormone-sensitive regions to early endocrine disruption.
Authors
- Hyuna Kim (ORCID: https://orcid.org/0000-0002-6127-2187)
- Bong Gun Lee (ORCID: https://orcid.org/0000-0002-4003-5529)
- Jongin Lee (ORCID: https://orcid.org/0000-0003-4337-8444)
- Junghwan Oh (ORCID: https://orcid.org/0000-0002-5837-0958)
- Hyun Ju Lee (ORCID: https://orcid.org/0000-0002-0335-5996)
- Gang Yi Lee
- Jeong-Kyu Hoh
- Seung Yang
- Sung-min Lim
Institutions
- Hanyang University Seoul Hospital (KR)
- Hanyang University (KR)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fendo.2025.1678738
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea