Mesenchymal stem cell-derived miR-125b-1-3p-abundant exosomes alleviate osteoarthritis by modulating the KDM6B-H3K27me3-FOXM1 axis
This study elucidates a novel molecular mechanism through which BMSC-Exos shuttle miR-125b-1-3p to alleviate OA by modulating the KDM6B/H3K27me3/FOXM1 signalling axis. These findings provide a theoretical rationale and identify promising therapeutic targets for the development of exosome-based therapeutic strategies against OA.
Authors
- Shuai Jiang (ORCID: https://orcid.org/0000-0003-3027-083X)
- Guoning Zhang
- Xiaoming Liu
- Yongqiang Xiao
- Bin Chai
- Pingping Li
- Jun Zhou
- Rui Cui
Institutions
- Second Military Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Changning Maternity and Infant Health Hospital (CN)
- Tongren Hospital (CN)
- Shanghai Pudong New Area Gongli Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1186/s13018-026-06765-9
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00