miR-1290 serves as a potential biomarker for osteoporotic fracture and regulates osteoblast function by targeting KDM5A
miR-1290 is downregulated in OP and OPF patients and promotes osteoblast function by targeting KDM5A, which highlights the role of the miR-1290/KDM5A axis in OPF and offers new insights for clinical diagnosis and targeted therapy.
Authors
- Xiaoqin Xu
- Qi Chen (ORCID: https://orcid.org/0000-0001-6221-8046)
- W Lu
- Wei-Bing Chen
- Xiaojing Zhou
- Jia Huang
Institutions
- First People’s Hospital of Jingmen (CN)
- Children's Hospital of Zhejiang University (CN)
- Zhejiang Provincial People's Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1186/s13018-026-06734-2
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00