From glycemic instability to neuropathic risk: a propensity score-matched retrospective cohort study

In this propensity score-matched cohort study, higher glycemic variability is independently and robustly associated with the presence and severity of diabetic peripheral neuropathy in patients with T2DM, even after accounting for HbA1c and other conventional risk factors. This association exhibits a dose-response relationship and is partially mediated by systemic inflammation. Our findings advocate for incorporating GV assessment into clinical practice for better DPN risk stratification and suggest that therapeutic strategies aimed at reducing glycemic variability may offer additional neuroprotective benefits.