Pituitary dysfunction in childhood after [ <sup>177</sup> Lu]Lu-DOTATATE therapy
We hypothesize that the GH and TSH deficiency in this case are caused by pituitary damage through binding of [ <sup><b>177</b></sup> Lu]Lu-DOTATATE to the somatostatin receptors in the pituitary gland. If [ <sup><b>177</b></sup> Lu]Lu-DOTATATE in the future becomes a more upfront treatment we strongly underline screening on pituitary dysfunction after exposure to [ <sup><b>177</b></sup> Lu]Lu-DOTATATE in childhood.
Authors
- Miranda P. Dierselhuis
- K. Wessel (ORCID: https://orcid.org/0009-0003-6928-5972)
- Hanneke M. van Santen (ORCID: https://orcid.org/0000-0002-6773-6931)
- Bart de Keizer
- Max Maria van Noesel (ORCID: https://orcid.org/0000-0001-7738-0353)
Institutions
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- Princess Máxima Center (NL)
- Cancer Genomics Centre (NL)
- Wilhelmina Children's Hospital (NL)
Publication Details
- Journal
- Journal of Pediatric Endocrinology and Metabolism
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1515/jpem-2025-0426
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00