UPLC-MS/MS Analytical Method for the Simultaneous Quantification of Diazepam, Nordazepam, and Oxazepam in Patients With Alcohol Dependence
We developed and validated a rapid, simple, and economic UPLC-MS/MS method for the quantification of DIA, NorD, and OXAZ in human serum. The method is well-suited for the determination of serum levels of DIA and its active metabolites in patients with alcohol dependence, and could be further applied to TDM and subsequent studies.
Authors
- Xiao-Jia Ni
- Zhan-Zhang Wang
- Yuqing Li (ORCID: https://orcid.org/0000-0003-1211-5529)
- Hao-Yang Lu
- Wen Yu-guan
- Shan-Qing Huang
- De-Wei Shang
- Huan-Shan Xie
- Wan-Ting Huang (ORCID: https://orcid.org/0009-0002-4061-2944)
- Xiao-Lin Li
Institutions
- Key Laboratory of Guangdong Province (CN)
- Zhuhai People's Hospital (CN)
- Guangdong 999 Brain Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- ALPHA PSYCHIATRY
- Published
- 2026-02-26
- DOI
- https://doi.org/10.31083/ap38973
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00