Single-cell profiling of tumor lineage plasticity and the immune microenvironment in transformed small cell lung cancer
Our findings provide a comprehensive understanding of the lineage plasticity and the immune landscape in T-SCLC, highlighting the crucial role of the stem-like cell cluster and ISG<sup>+</sup> lymphocytes in LUAD-to-SCLC transformation.
Authors
- J. Joshua Yang (ORCID: https://orcid.org/0000-0001-8242-7531)
- Lei Yang (ORCID: https://orcid.org/0000-0002-2785-8635)
- Jie Huang (ORCID: https://orcid.org/0000-0001-6191-4912)
- Junjian Wang
- Chen Yong-lu
- Weiye Huang
- Zhenhua Zhang
- Qing Zhou
- Guodi Cai
- Jian Zhang
Institutions
- Sun Yat-sen University (CN)
- National Medical Products Administration (CN)
- Ganzhou People's Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1186/s12967-026-07940-6
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00