Efficacy and safety of immune checkpoint inhibitors combined with chemoradiotherapy in locally advanced cervical cancer: a systematic review and meta-analysis
This meta-analysis supports the combination of ICIs with CCRT as an effective treatment strategy for LACC, improving PFS and ORR without a significant increase in severe toxicity. However, further studies with mature OS data and exploration of optimal ICI timing are warranted.
Authors
- Siyuan Zeng (ORCID: https://orcid.org/0000-0002-5924-9957)
- Chao Xiao (ORCID: https://orcid.org/0000-0001-8423-2789)
- Ruiqi Wang
- Xue Xiao
- Luying Li
Institutions
- Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
- Zigong First People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fphar.2026.1766157
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China