CAPZA1 deficiency disrupts sperm flagellar structure and motility, potentially involving the p300/SLC7A11 pathway

CAPZA1 deficiency impairs sperm motility and flagellar architecture through disrupted cytoskeletal protein regulation and redox imbalance, and represents a novel genetic contributor to asthenozoospermia.

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Publication Details

Journal
Frontiers in Endocrinology
Published
2026-03-04
DOI
https://doi.org/10.3389/fendo.2026.1744836
Primary Topic
Sperm and Testicular Function
Type
article
Field-Weighted Citation Impact
0.00
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article

CAPZA1 deficiency disrupts sperm flagellar structure and motility, potentially involving the p300/SLC7A11 pathway

Y T Li, Hailing Ruan, Hui Lu, Liqiang Zhao et al.
Frontiers in Endocrinology
Sperm and Testicular Function
article

CAPZA1 deficiency disrupts sperm flagellar structure and motility, potentially involving the p300/SLC7A11 pathway

Y T Li, Hailing Ruan, Hui Lu, Liqiang Zhao, Anguo Wang, Guoxuan Li, Jiajia Hu
article en

Abstract

CAPZA1 deficiency impairs sperm motility and flagellar architecture through disrupted cytoskeletal protein regulation and redox imbalance, and represents a novel genetic contributor to asthenozoospermia.

Frontiers in EndocrinologyVol. 17
Children's Medical Center (US), Hainan Medical University (CN), University of Hong Kong (HK)
Openalex Percentile: Top 31%
Sperm and Testicular Function
DOIOpen Access PDFOpenAlex
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