Structural Alterations and Cognitive Impairment in Late-Onset Depression: A Reverse Correlation Analysis

Alterations in the internal structure of the temporal lobe may represent potential anatomical biomarkers for the early prediction of Alzheimer's disease, providing novel insights into the pathophysiological mechanisms underlying LOD-related MCI. The research framework proposed in this study effectively addresses the challenge of detecting subtle intergroup anatomical differences in studies with limited sample sizes. Moreover, the reverse correlation approach is not restricted to multilayer neural networks; as machine learning models become increasingly powerful and accessible, this method offers a practical and interpretable alternative for exploratory neuroimaging research.