Assessment of noninvasive quantification of [18F]SynVesT-1 with simplified reference tissue model 2 in an adolescent and youth cohort

The suitability of the white matter centrum semiovale (CS) as a pseudo-reference region for simplified reference tissue model 2 (SRTM2) with [¹⁸F]SynVesT-1 PET has not been evaluated in youth cohorts. We aimed to assess noninvasive quantification methods and determine the minimum scan time needed in a sample of youth with mental health challenges. Thirty-five youth participants (16–25 years old) from the Toronto Adolescent & Youth cohort underwent 120-minute scans with arterial sampling. Binding potential (BPND) was estimated using one-tissue compartment model (1TCM) as a reference method. The SRTM2 was then applied, with k2′ parameter either set to population average (k2 from 1TCM) or estimated individually by initial coupled fitting in a two-step procedure. Standardized uptake value ratio − 1 (SUVR − 1, 60–90 min) was compared with 1TCM-derived BPND. Linear regression and percent bias analyses were performed. Time stability was assessed using several truncated scans (40–100 min). CS volume (1.7 ± 0.2 mL), VT (4.0 ± 0.6 mL/cm3) and k2 (0.031 ± 0.004 min− 1) were consistent with previously reported values. The population-based k2′ (0.031) and SUVR − 1 closely matched 1TCM results (R2 > 0.9, < 5% mean bias). The coupled-k2′ approach underestimated several regions (R2 > 0.9, > 10% bias in some regions). Minimum scan durations were 60 min for 1TCM, 90 min for fixed-k2′, and ≥ 100 min for coupled-k2′. The population-based k2′ and semiquantitative SUVR–1 provide accurate [¹⁸F]SynVesT-1 quantification in youth with diverse clinical symptoms, supporting their use as noninvasive methods, and allowing scan time reduction to 90 minutes. This will facilitate its clinical use and wider applicability.

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Journal
European Journal of Nuclear Medicine and Molecular Imaging
Published
2026-03-05
DOI
https://doi.org/10.1007/s00259-026-07818-1
Primary Topic
Medical Imaging Techniques and Applications
Type
article
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article

Assessment of noninvasive quantification of [18F]SynVesT-1 with simplified reference tissue model 2 in an adolescent and youth cohort

Lucas Narciso, Alexia Polillo, Kimberly L. Desmond, John D. Griffiths et al.
European Journal of Nuclear Medicine and Molecular Imaging
Medical Imaging Techniques and Applications
article

Assessment of noninvasive quantification of [18F]SynVesT-1 with simplified reference tissue model 2 in an adolescent and youth cohort

Lucas Narciso, Alexia Polillo, Kimberly L. Desmond, John D. Griffiths, Judy Truong, Kristin Cleverley, Madison Aitken, Anne L. Wheeler, Neil Vasdev, Muhammad Omair Husain, Carme Uribe, Isabelle Boileau, Érica Leandro Marciano Vieira, Martin Rotenberg, Shreejoy J. Tripathy, Darren Courtney, Hsiang-yuan Lin, Yuliya S. Nikolova, Carly Albaum, Sang Soo Cho, Daniel Felsky, Erin W. Dickie, Lisa D. Hawke, Maia Zilberman, Cassie Cote, Robert D. Levitan, Stephen P. Lewis, Tristan Glatard, Stephanie H. Ameis, the TAY Cohort Study Team, Wei Wang, Claire de Oliveira, Lena C. Quilty, Sean A. Kidd, Wanda Tempelaar, Brendan F. Andrade, M. Omair Husain, Peter Szatmari, Benjamin I. Goldstein, Aristotle N. Voineskos, Yona Lunsky, Hayley Hamilton, George Foussias, Louise Gallagher, Vanessa Gonçalves, Nicole Kozloff, Meng-Chuan Lai, Lujia Yu
article en

Abstract

The suitability of the white matter centrum semiovale (CS) as a pseudo-reference region for simplified reference tissue model 2 (SRTM2) with [¹⁸F]SynVesT-1 PET has not been evaluated in youth cohorts. We aimed to assess noninvasive quantification methods and determine the minimum scan time needed in a sample of youth with mental health challenges. Thirty-five youth participants (16–25 years old) from the Toronto Adolescent & Youth cohort underwent 120-minute scans with arterial sampling. Binding potential (BPND) was estimated using one-tissue compartment model (1TCM) as a reference method. The SRTM2 was then applied, with k2′ parameter either set to population average (k2 from 1TCM) or estimated individually by initial coupled fitting in a two-step procedure. Standardized uptake value ratio − 1 (SUVR − 1, 60–90 min) was compared with 1TCM-derived BPND. Linear regression and percent bias analyses were performed. Time stability was assessed using several truncated scans (40–100 min). CS volume (1.7 ± 0.2 mL), VT (4.0 ± 0.6 mL/cm3) and k2 (0.031 ± 0.004 min− 1) were consistent with previously reported values. The population-based k2′ (0.031) and SUVR − 1 closely matched 1TCM results (R2 > 0.9, < 5% mean bias). The coupled-k2′ approach underestimated several regions (R2 > 0.9, > 10% bias in some regions). Minimum scan durations were 60 min for 1TCM, 90 min for fixed-k2′, and ≥ 100 min for coupled-k2′. The population-based k2′ and semiquantitative SUVR–1 provide accurate [¹⁸F]SynVesT-1 quantification in youth with diverse clinical symptoms, supporting their use as noninvasive methods, and allowing scan time reduction to 90 minutes. This will facilitate its clinical use and wider applicability.

European Journal of Nuclear Medicine and Molecular Imaging
Centre for Addiction and Mental Health (CA), University of Toronto (CA), York University (CA), University of South Florida (US), Scarborough Health Network (CA), Hospital for Sick Children (CA), Public Health Ontario (CA), Institute for Work & Health (CA), University of Guelph (CA)
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Medical Imaging Techniques and Applications
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