The role of immune regulation in peripheral nerve regeneration: functions of inflammatory cells and cytokines

The integration of immunology and nerve regeneration research is opening new frontiers for treatment. Harnessing the regenerative potential of the immune system while restraining its detrimental effects-through approaches such as precision modulation of macrophage polarization, neutrophil extracellular trap regulation, and T cell-Schwann cell crosstalk targeting-offers encouraging prospects for overcoming the current challenges in peripheral nerve repair.

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Publication Details

Journal
Frontiers in Pharmacology
Published
2026-03-04
DOI
https://doi.org/10.3389/fphar.2026.1735833
Primary Topic
Nerve injury and regeneration
Type
article
Field-Weighted Citation Impact
0.00
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article

The role of immune regulation in peripheral nerve regeneration: functions of inflammatory cells and cytokines

Yan Zhang, H.-Q. Zhang, Xiangjun Meng, Yun Su et al.
Frontiers in Pharmacology
Nerve injury and regeneration
article

The role of immune regulation in peripheral nerve regeneration: functions of inflammatory cells and cytokines

Yan Zhang, H.-Q. Zhang, Xiangjun Meng, Yun Su, Wenguang Wu, Min Nuo, Haochen Jiang
article en

Abstract

The integration of immunology and nerve regeneration research is opening new frontiers for treatment. Harnessing the regenerative potential of the immune system while restraining its detrimental effects-through approaches such as precision modulation of macrophage polarization, neutrophil extracellular trap regulation, and T cell-Schwann cell crosstalk targeting-offers encouraging prospects for overcoming the current challenges in peripheral nerve repair.

Frontiers in PharmacologyVol. 17
Affiliated Zhongshan Hospital of Dalian University (CN)
Partnerships for the goals
Openalex Percentile: Top 35%
Nerve injury and regeneration
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