Uncovering the mechanism of arecoline’s effect on oral submucous fibrosis: integrating transcriptomics and in vitro and in vivo experiments
These findings highlight the Hippo signaling pathway as a critical mediator of arecoline-induced OSF, providing novel insights for therapeutic targeting and mechanistic exploration in OSF management.
Authors
- Zhenkui Liu
- Yin OuYang
- Wanling Ning (ORCID: https://orcid.org/0009-0009-7056-2897)
- Jian Yi
- Bowei Chen (ORCID: https://orcid.org/0000-0002-8695-2146)
- Fanzuo Zeng
- Jiongwei Tang
Institutions
- Hong Kong Baptist University (HK)
- First Affiliated Hospital of Hunan University of Traditional Chinese Medicine (CN)
- Hunan Academy of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fphys.2026.1768602
- Primary Topic
- Oral Health Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00