Dual-functional sulfonated PEEK implants via graphene oxide–mediated BMP-2 gene delivery: enhanced osteogenic and antibacterial performance in vitro
The SPEEK-(GO-PEG/pBMP-2) platform simultaneously promotes osteogenesis through localized BMP-2 gene delivery and provides robust antibacterial protection via GO. This dual-functional design addresses two major limitations of PEEK implants, offering a promising strategy for next-generation orthopedic biomaterials.
Authors
- Maihefuzi Aishan
- Bumairemu Yiminjiang (ORCID: https://orcid.org/0009-0007-8678-7922)
- Refeina Tuerxun
- Adilai Abula
- Yueying Pan
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- Stomatology Hospital (CN)
- Xinjiang Uygur Autonomous Region Education Department (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-03-04
- DOI
- https://doi.org/10.3389/fmed.2026.1763692
- Primary Topic
- Graphene and Nanomaterials Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00